GOURI Collagen Filler activates natural collagen production
What makes GOURI so unique?
Unlike other high polymer products that are not completely liquid, GOURI is a ready-to-use liquid solution that can be injected directly. This eliminates the need to mix the high polymer material powder with saline solution as is common practice. In addition, the resulting end product has a gel-like structure, so that the agent is difficult to spread.
Dual Action
Unlike conventional hyaluronic acid products that primarily offer plumping and filling effects, the GOURI Collagen Filler offers a dual benefit. Beyond providing immediate volume enhancement and visible wrinkle reduction post-injection, GOURI Filler also stimulates the regeneration of natural skin collagen, promoting long-term skin rejuvenation.
What is GOURI and what is PCL?
DEXLEVO, a company from South Korea, had invented the world's first liquid polymer filler, also known as GOURI. GOURI is made of liquid polycaprolactone (PCL), and the liquid state makes GOURI injectable.
PCL can be degraded by the human body and hence, its popular use as an implantable biomaterial.
PCL has been approved by the Food and Drug Administration (FDA) in specific applications used in the human body such as drug delivery device and sutures. There is also a PCL-based microsphere dermal filler belonging to the collagen stimulator class, also known as Ellansé.
By stimulating collagen product, PCL-based products can reverse facial ageing features such as volume loss and contour laxity, providing a good long-lasting natural effect.
As such, GOURI, also made of PCL, has anti-aging properties and is biodegradable as well. Being in a liquid form, GOURI can spread evenly throughout the entire face and hence promotes natural skin collagen synthesis, which helps your skin age more gracefully.
GOURI VS Dermal Fillers
GOURI is developed using DEXLEVO's Caollagenesis-Enabled Solubilized Active and Biodegradable Polymer Technology (CESABP) technology that enables regeneration of natural skin collagen without the use of microparticles.
There are hyaluronic acid (HA)- base fillers and PCL-base fillers. Dermal fillers may also have a regenerative impact on the collagen. Due to the nature and shape of particles, dermal filler cannot be injected evenly into the skin. As a result, these fillers are limited to focal areas only. For example, we can use Ellanse (a PCL-based filler) to fill up certain types of acne scars.
As such, GOURI is more for a generalized effect while dermal fillers are more targeted and focused on areas that have a specific volume defect.
GOURI VS Profhilo
While both GOURI and Profhilo only require 10 injection points, they are made of different substances. GOURI is made with fully solubilized liquid form of PCL while Profhilo is made from Hyaluronic Acid (HA). Profhilo can help with hydrating the skin as well as giving a gentle glow to the skin, while GOURI helps by giving a gentle lifting effect to the face in a generalized fashion.
Benefits of GOURI:
- Fewer injection points, as compared to other types of skin injectables, except Profhilo which requires the same injection points
- Transforms into a three-dimensional matrix and encourages fibroblasts formation
- Stimulates new collagen production
- Increases skin elasticity and rendering a gentle facelift
Treatment Procedure
GOURI is carefully injected into 5 specific points on each side of the patient's face. A layer of numbing cream will be applied prior to the procedure.
GOURI is a groundbreaking antiaging solution for the entire face, featuring the world's only solubilized, biodegradable, and biocompatible PCL injectable. It is not a filler with a localized impact or a temporary skin booster.
It spreads evenly throughout the entire face and promotes natural skin collagen synthesis, which helps your skin age more gracefully.
DEXLEVO's liquid polymer filler is unique among fillers in that it encourages skin collagen renewal. Existing fillers also have a regenerative impact on the collagen. However, because they are in the shape of particles, they cannot be injected evenly into the skin. As a result, these fillers are limited to topical areas such as the nasolabial folds. DEXLEVO, on the other hand, circumvented this constraint. When a liquid version of a high molecular component is injected into the skin, it can be used in various regions by rebuilding collagen around the skin and changing it into little particles within the skin.
DEXLEVO obtained a European CE registration for the liquid polymer filler 'GOURI' in the first half of 2021, creating the groundwork for its global market debut.
GOURI's primary characteristics include the following:
- Collagen stimulator of the highest quality
- PCL is available in a fully soluble liquid form (polycaprolactone)
NEOCOLLAGENESIS and its mechanism of action:
- To begin, inject GOURI.
- GOURI absorbs easily into the skin
- It transforms into a three-dimensional matrix and encourages fibroblasts
- Formation of new collagen
- Increased skin elasticity and facelift
GOURI distributes naturally across the entire face:
- There is no requirement for several injection locations.
- There is no requirement to form the application portion.
- After application, a gentle massage is sufficient.
FAQs
What are the primary advantages of GOURI?
GOURI is the first injectable liquid PCL (polycaprolactone). GOURI revitalizes our skin by stimulating collagenesis throughout the face. GOURI, which spreads organically across the entire face, stimulates collagen synthesis, which has diminished due to skin aging.
How long does it take to see initial results following the application?
The patient's condition determines it. After injection, neocollagenesis takes time to occur. Typically, the first visual benefits are visible after 1-2 weeks.
How long is GOURI active?
It is subjective. PCL is a substance with a high molecular weight. PCL is typically destroyed in the body over 6-12 months.
Is GOURI safe to use on the body?
We recommend using GOURI only on the face. We are now gathering clinical data on additional indications, such as injections in the hand and neck.
What distinguishes GOURI from other high-polymer products?
It is opposed to other high-polymer products. Currently, available goods are not completely liquid. They are created by combining powdered high-polymer materials (PCL and PLLA) with saline or CMC gel. As a result, they cannot spread over the face and pose a significant danger of problems. They affect just the portion that is confined. Additionally, there is a risk of hypercorrection when an excessive amount of material is injected. GOURI, the world's first liquid PCL injectable, spreads evenly across the entire face.
How is GOURI composed?
Clinical data on 21% of PCL / just PCL. DEXLEVO has completed Phase 1 and Phase 2 clinical trials involving over 200 participants.
Which protocol is recommended?
We propose three sessions separated by four weeks. Following the third session, additional 1 or 2 treatments with a 3-6 month interval might be used to maintain the collagen rate.
Is it possible to dissolve GOURI after the injection?
PCL is not soluble post-injection. GOURI does not provide immediate cosmetic alterations. That is, there is no need to dissolve it.
Can I use GOURI with other Botox, HA fillers, or PRP?
We recommend a one-month delay between other treatments. Compatibility with different products is one of GOURI's strong points. You can combine non-crosslinked skin boosters and Botox. However, do not combine GOURI with any other product. We advocate a one-month delay between treatments with HA fillers and other cross-linked materials.
What certificates does GOURI have?
GOURI has received CE certification. Our manufacturing facilities are all ISO 13485 certified. KFDA is currently being developed and is expected to be completed next year.
What exactly is the CESABP technology?
Solubilized Active and Biodegradable Polymer Technology Enabled by Collagen DEXLEVO's patented technology stimulates natural skin collagen regeneration and rejuvenates your skin without the use of microparticles.
Popular science on Korean new product Richesse callafilo Richesse Double Beauty Collagen - product information, effects, and maintenance time
As age increases, fine lines will gradually appear on the surface of the skin, the fullness of the face will slowly disappear, and aging will appear. This is a normal phenomenon due to the loss of collagen. As we age, collagen is lost less quickly than it can be replenished.
Richesse callafilo is an absorbable collagen tissue supplement composed of high-purity collagen. It can effectively penetrate into the dermis, release HA and stimulate collagen regeneration, improve the internal structure of the skin, and make the skin tighter. It is really elastic and brings long-lasting and stable "skin tightening" effect. Minimizing the immune response by removing part of the antigen's terminal peptides allows for an increase in collagen in the skin tissue.
Main ingredients
PLA (polylactic acid) - 170mg
HA (sodium hyaluronate) - 30mg
What do PLA particles do?
Promote collagen production, improve skin texture, and tighten skin.
Polylactic acid is a natural organic acid that can maintain the acidic environment of the skin and adjust the pH value.
It has the function of moisturizing and hydrating, making the skin healthier.
It is completely decomposed after a certain period of time in the human body and is biodegradable and bioabsorbable.
Advantages of Richesse Collafilo
1. New Korean product, one shot has double effects
Reese Double Beauty contains two ingredients, HA and PLA, which can maintain the skin's moisture balance to the maximum effect. PLA can proliferate collagen to achieve dual effects.
2. High safety, no adverse reactions
The main ingredients of Ruisi Shuangmei are compatible with the body, can be absorbed and decomposed in the body, and there will be no adverse reactions such as rejection.
3. Good improvement effect, available in many parts
For nasolabial folds, sunken cheeks, marionette lines, tear troughs, Apple machine dents, etc., Reese Shuangmei Collagen is suitable for all. It can smooth fine lines, stimulate collagen regeneration, comprehensively shape and lift, and is more comfortable after use.
4. Short-term results and longer-lasting effects
After using Reese Double Beauty Collagen, you can see immediate results. You can immediately witness plump skin, pores and fine lines are well improved. The maintenance effect is more significant 2-15 weeks after use.
Lucizen6% Therafill 3% Collagen Dermal Filler Gel Injection for Nasolabial Folds Fill Lacrimal Groove Fill Facial Gain Korea Lucizen Therafill Collagen Filler
Collagen is the most abundant protein in the human body
Skin, bones, cartilage, ligaments, and cornea all have their presence, with a unique triple helix structure that has diverse biological functions, such as the support and protection of a steel skeleton, and the strong toughness and stretchability of a spring that can promote wound healing and tissue repair. In addition, it can retain moisture in the dermis, maintain the humidity and elasticity of connective tissue, and make the skin smooth, soft, and crystal clear.
Facial Gain collagen maintenance time:
Its maintenance period depends on the physical fitness, generally up to more than one year, depending on the injection technique, implant depth, implant site, patient age, and living habits, and have different effects. In addition to instantly smoothing wrinkles and shaping, it can nourish and activate the skin at the same time, increase skin elasticity, and improve sagging skin on the face.
Post-operative care of Facial Gain Collagen:
(1) Within 48 hours after injection, keep the injection site still, do not touch or press, and avoid frequent movements of facial muscles such as crying and laughing, so as to maintain the uniform distribution of fillers at the injection site. It is not advisable to apply heavy makeup on the implantation site within two days;
(2) Within 24 hours after injection, do not use cosmetics on the whole face, do not touch water or be polluted; within 72 hours after injection, do not apply irritating cosmetics on the injection site and the surrounding parts of the injection, and do not use saunas or do facials within 1 month. Laser or photoelectric beauty;
(3) Do not smoke, drink alcohol, eat spicy and other irritating foods after injection, and avoid staying up late and exposing to extreme sunlight and other rays;
(4) Keep a good mood;
(5) For lip augmentation, avoid pursing lips and hot food within two days.
Who is suitable for collagen injection
Improve black circles under the eyes
Including: vascular type, structural type, mixed type, and pigmented type.
Improve skin tone and texture
Including but not limited to: lack of elasticity, coarse pores, facial fine lines, scars, etc.
Mild to moderate overall skin and soft tissue relaxation
Including but not limited to: eyelid skin relaxation, cheek skin relaxation, mandibular edge skin relaxation, neck skin relaxation, etc.
Facial contour modification and beautification
Including: adjustment of aesthetic plane of facial contour.
- LUCIZEN is a medical device that has obtained CE certification in Europe, is registered with the US FDA as a raw material drug, and is licensed in Korea. It has excellent efficacy and safety, and is an approved wrinkle-improving filler.
This treatment is non-operative cosmetic procedure performed by medical specialist. It does not require allergy testing, features short medical procedure and recovery time. As it has a low incidence rate of adverse events such as edema and erythema. Low chance of side effects in returning to daily life after medical procedures
THERAFILL atelocollagen filler is a sterile and highly purified collagen filler,
which is dissolved in phosphate-buffered solution to enable soft-tissue
augmentation by intradermal injection.
TheraFill is biocollagen dermal filler manufactured by the Company's patented
technology.
It is CE approved, sterile device composed of highly purified atelocollagen
dispersed in phosphate-buffered physiological saline, and filled in 1ml syringe,
used for correction of wrinkles, nasolabial folds, scars and other soft tissue defects.
The porcine based atelocollagen is much safer and no risky for BSE, unlike other
collagen injections which is made from bovine protein. Because it is structurally
similar to human collagen, this product does not require skin testing.
Collagen is a fibrous extracellular protein forming connective tissue of dermis.
Collagen is inherently low in antigenicity and the most of its antigenicity are
assumed to result from the telopeptide regions.
TheraFill Atelocollagen Filler shows minimal antigen reaction because of the lack of
telopeptides by treatment with pepsin. It is made of porcine collagen (from piglets),
not bovine collagen.
Atelocollagen shows excellent properties for implantation in human body because
porcine collagen is structurally similar to human collagen.
Advantages
Implanted TheraFill maintains collagen mass which replaced by normal surrounding tissue
- Providing stable scaffolding structure
- Inducing cell migration with enriched sites for adherent cells
- Optimizing cell conduction into the scaffold
- Advancing remodeling phase
- Promoting fat cell viabilities
- Ideal biocompatibilities
- No risk for BSE
- No skin test required
- No antigenicity
- Less side effects ( erythema, swelling )
Detailed Photos
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